Molecular regulation of human IgE synthesis
نویسندگان
چکیده
منابع مشابه
Differential regulation of IgG1 and IgE synthesis by interleukin 4
IL-4/B cell stimulatory factor-1 is a T cell-derived lymphokine that has been shown to enhance IgG1 and IgE and to suppress IgG3 and IgG2b secretion by B cells stimulated with bacterial LPS. We show here that the stimulation of IgG1 and IgE secretion in response to rIL-4 is differentially regulated. The dose-response curve for IgG1 production is bimodal with peaks at 100 and 10,000 U/ml. IgE pr...
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Interleukin 4 (IL-4)/B cell stimulatory factor 1 is a T cell-derived lymphokine that has effects on virtually all cells of hematopoietic origin. In particular, it strikingly enhances the secretion of IgGI and IgE in vitro and of IgE in vivo (1-10). IL-4 acts on cells that lack surface IgG to cause IgG1 production (1, 11), strongly suggesting that it promotes Ig class switching rather than the s...
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BACKGROUND Our laboratory has demonstrated previously that human tonsillar B lymphocytes express IL-13 mRNA OBJECTIVE: We sought to investigate IL-13 production by human B cells and the association between B cell-derived IL-13 and IgE secretion. METHODS Human B lymphocytes were isolated from tonsils and purified by means of rosetting with sheep RBCs or positive or negative selection with magn...
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1Hua Huang, Department of Biomedical Research, National Jewish Health, Denver, CO, USA 2Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, USA 1Yapeng Li, Department of Biomedical Research, National Jewish Health, Denver, CO, USA 1Jinyi Liang, Department of Biomedical Research, National Jewish Health, Denver, CO, USA 3Department of Parasitology, Zh...
متن کاملRegulation of the IgE response
IgE was the last of the five immunoglobulin classes to be discovered and is the antibody that is responsible for much of human type I allergic disease. This review summarizes recent developments with respect to control of IgE synthesis with an emphasis on Th2 (T helper 2) control and regulation using IgE Fc receptors.
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ژورنال
عنوان ژورنال: Allergology International
سال: 1999
ISSN: 1323-8930
DOI: 10.1046/j.1440-1592.1999.00124.x